496802-01-8

Upstream product

• 496801-90-2 2-(2-fluorophenyl)-3-hydroxy-4-methyl-5-(3-methoxyphenyl)-2,4-cyclopentadienone 
• 109-84-2 2-hydroxyethylhydrazine 

Downstream Products

• 496802-05-2 4-(3-methoxyphenyl)-5-methyl-6-(2-fluorobenzyl)-2-(2-bromoethyl)-pyridazin-3-one 

Relevant academic research and scientific papers

Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, R1, R2, R3a, R3b, R4, R5, R6, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.