496802-87-0

Upstream product

• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 496802-83-6 [(S)-2-(6-oxo-1,3,4,11a-tetrahydro-2H,6H-pyrido[1,2-b]isoquinolin-(11Z)-ylidene)]acetic acid 
• 353764-20-2 methyl [(S)-2-(6-oxo-1,3,4,11a-tetrahydro-2H,6H-pyrido[1,2-b]isoquinolin-(11Z)-ylidene)]acetate 

Relevant academic research and scientific papers

Influence of quadrupolar interactions on the crystal packing of organic compounds: The pentafluorophenyl ester of a tricyclic α,β-unsaturated-γ-amino acid

The single crystal X-ray diffraction structure of (-)-pentafluorophenyl(Z,S,S)-2-(6-oxo-1,3,4,6,11,11a-hexahydro-2H-pyrido[1, 2-b]isoquinolin-11-yliden)acetate (1) is reported. We have found that the crystal packing of the α,β-unsaturated-γ-amino acid derivative 1 is mainly determined by the interaction between the two aromatic rings, namely the benzenic type and the pentafluorinated ring. The crystal packing of 1 shows a herringbone (zig-zag) structure, that is quite typical of aromatic compound with intermolecular arene-arene interactions. The benzenic and the fluorinated phenyl rings in 1 are in a matched face-to-face arrangement. The origin of this interaction can be ascribed to a favourably quadrupolar interaction between both types of aromatic ring. The results reported in the present paper indicate that the pentafluorophenyl ester functionality can be a useful building block in crystal engineering.

Novel Peptide-Heterocycle Hybrids: Synthesis and Preliminary Studies on Calpain Inhibition

New peptidic compounds, having peptide chains linked to bi- and tricyclic heterocycles (peptide-heterocycle hybrids), have been synthesized. The heterocyclic components are derivatives of partially reduced isoquinoline and pyrido[1,2-b]isoquinoline bearin