496804-84-3Relevant academic research and scientific papers
Synthesis of thieno[2,3-b][1,6]naphthyridines and pyrimido[4',5':4,5] thieno[2,3-b][1,6]naphthyridines
Abdel-Wadood, Fatma K.,Abdel-Monem, Maisa I.,Fahmy, Atiat M.,Geies, Ahmed A.
experimental part, p. 89 - 94 (2009/07/18)
3-Cyano-6-methyl-5,6,7,8-tetrahydro[1,6]naphthyridine-2(1H)-thione (3a) and 3-cyano-6-methyl-4-(2'-thienyl)-5,6,7,8-tetrahydro[1,6]naphthyridine-2(1H)- thione (3b) were reacted with a-halo compounds to give the intermediates 4a-j which upon refluxing in ethanolic sodium ethoxide afforded the thieno[2,3-b][1,6]naphthyridine derivatives 5a-l. Further annellation of pyridine and pyrimidine rings to the remaining free bond of the fused thiophene ring was achieved, providing tetrahydro-pyrido[2',3':4,5]- and -pyrimido[4',5':4,5]-thieno[2,3-b][1,6]naphthyridines. Some of the synthesised compounds were screened against different strains of bacteria.
