496808-12-9

Upstream product

• 496808-11-8 ethyl (2S,3R,4R,5R)-4-(benzyloxy)-2,3-isopropylidenedioxy-1,6-dioxa-7-azaspiro[4.5]dec-7-ene-8-carboxylate 
• 34370-91-7 3-O-benzyl-1,2-O-isopropylidene-α-D-xylofuranose 
• 176098-48-9 (3aR,4R,6aR)-4-(benzyloxy)-2,2-dimethyl-5-methylenetetrahydrofuro[2,3-d][1,3]dioxole 
• 29580-99-2 (3aR,4S,5R,6aR)-4-(benzyloxy)-5-(iodomethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole 

Relevant academic research and scientific papers

Hetero-Diels-Alder additions to pent-4-enofuranosides: Concise synthesis of hydroxylated pyrrolizidines

A new facile method for the synthesis of hydroxylated pyrrolizidines of the alexine family has been developed, which involves hetero-Diels-Alder addition of ethyl 2-nitrosoacrylate to pent-4-enofuranosides and a further two-step reductive ring opening-ring closure treatment of the cycloadduct.