496838-02-9

Basic information

• Product Name: Benzamide, N-[1-methyl-6-(phenylmethoxy)-1H-benzimidazol-2-yl]-
• CAS NO: 496838-02-9
• Molecular Formula: C22H19N3O2
• Molecular Weight: 357.412
• Mol File: 496838-02-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[1-methyl-6-(phenylmethoxy)-1H-benzimidazol-2-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[1-methyl-6-(phenylmethoxy)-1H-benzimidazol-2-yl]-(496838-02-9)
• EPA Substance Registry System: Benzamide, N-[1-methyl-6-(phenylmethoxy)-1H-benzimidazol-2-yl]-(496838-02-9)

Safety Data

• Hazardous Substances Data: 496838-02-9(Hazardous Substances Data)

Upstream product

• 496837-94-6 5-(benzyloxy)-N-methyl-2-nitroaniline 
• 496837-95-7 5-(benzyloxy)-N₁-methylbenzene-1,2-diamine 
• 221040-07-9 4-benzyloxy-2-fluoro-1-nitrobenzene 
• 532-55-8 Benzoyl isothiocyanate 

Relevant articles and documents

Efficient solution phase synthesis of 2-(N-acyl)-aminobenzimidazoles

An efficient solution phase protocol for the synthesis of 2-(N-acyl)-aminobenzimidazoles is reported. The 2-(N-acyl)-aminobenzimidazole ring system was assembled using SNAr reactions, nitro group reduction, acylthiourea formation and cyclization with EDC. The acyl protected 2-aminobenzimidazole derivatives were obtained in high yield and purity without purification of intermediates or final products. This reaction sequence eliminates the use of highly toxic cyanogen bromide, a reagent commonly used to prepare the 2-aminobenzimidazole ring system.