496841-81-7

Basic information

• Product Name: Benzoic acid, 5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-fluoro-, ethyl ester
• CAS NO: 496841-81-7
• Molecular Formula: C15H20FNO4
• Molecular Weight: 297.327
• Mol File: 496841-81-7.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-fluoro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-fluoro-, ethyl ester(496841-81-7)
• EPA Substance Registry System: Benzoic acid, 5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-fluoro-, ethyl ester(496841-81-7)

Safety Data

• Hazardous Substances Data: 496841-81-7(Hazardous Substances Data)

Upstream product

• 496842-05-8 5-azidomethyl-2-fluoro-benzoic acid ethyl ester 
• 423174-83-8 ethyl 5-(bromomethyl)-2-fluorobenzoate 
• 496841-90-8 ethyl 2-fluoro-5-methylbenzoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 496842-06-9 5-aminomethyl-2-fluoro-benzoic acid ethyl ester 

Relevant articles and documents

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates

Novel, potent, and highly selective classes of thrombin inhibitors were identified, which resulted from judicious combination of P4-aromatics and P2-P3-heterocyclic dipeptide surrogates with weakly basic (calcd pKa ～non-basic - 8.6) bicyclic P1-arginine mimics. The design, synthesis, and biological activity of achiral, non-covalent, orally bioavailable inhibitors NC1-NC44 featuring P1-indazoles, benzimidazoles, indoles, benzotriazoles, and aminobenzisoxazoles is disclosed.