496848-40-9

Upstream product

• 496848-38-5 tert-butyl (2RS,3S,5R)-2-[4-amino-2-oxopyrimidin-1(2H)-yl]-5-[(tert-butyldimethylsilyloxy)methyl]-3-(trifluoromethyl)pyrrolidine-1-carboxylate 
• 496848-33-0 tert-butyl (2R,3S,5R)-2-(acetyloxy)-5-[(tert-butyldimethylsilyloxy)methyl]-3-(trifluoromethyl)pyrrolidine-1-carboxylate 
• 496848-31-8 ethyl 4-[(tert-butoxycarbonyl)amino]-5-(tert-butyldimethylsilyloxy)-2-(trifluoromethyl)pentanoate 
• 496848-32-9 tert-butyl (2R,3S,5R)-2-hydroxy-5-[(tert-butyldimethylsilyloxy)methyl]-3-(trifluoromethyl)pyrrolidine-1-carboxylate 
• 496848-29-4 ethyl 3-[(S)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidin-4-yl]-2-(trifluoromethyl)propanoate 
• 496848-30-7 ethyl 4-[(tert-butoxycarbonyl)amino]-5-hydroxy-2-(trifluoromethyl)pentanoate 
• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 496848-44-3 2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-trifluoromethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of 2′,3′-dideoxy-2′-trifluoromethyl-N-azanucleosides

The trifluoromethylation of (Z)/(E)-tert-butyl (4S)-4-(2′-ethoxycarbonyl-2′-bromoprop-1′-enyl)-2,2- dimethyloxazolidine-3-carboxylate (4), which is derived from chiral serine aldehyde, yields α-trifluoromethyl-α,β-unsaturated ester 1. Compound 1 is used as a key intermediate for the synthesis of a number of 2′,3′-dideoxy-2′-trifluoromethyl-N-azanucleosides.