49685-05-4Relevant academic research and scientific papers
1-Aminopyridinium Ylides as Monodentate Directing Groups for sp3 C-H Bond Functionalization
Le, Ky Khac Anh,Nguyen, Hanh,Daugulis, Olafs
supporting information, p. 14728 - 14735 (2019/10/11)
1-Aminopyridinium ylides are efficient directing groups for palladium-catalyzed β-arylation and alkylation of sp3 C-H bonds in carboxylic acid derivatives. The efficiency of these directing groups depends on the substitution at the pyridine moiety. The unsubstituted pyridine-derived ylides allow functionalization of primary C-H bonds, while methylene groups are unreactive in the absence of external ligands. 4-Pyrrolidinopyridine-containing ylides are capable of C-H functionalization in acyclic methylene groups in the absence of external ligands, thus rivaling the efficiency of the aminoquinoline directing group. Preliminary mechanistic studies have been performed. A cyclopalladated intermediate has been isolated and characterized by X-ray crystallography, and its reactivity was studied.
Synthesis of N-(Carbonylamino)-1,2,3,6-tetrahydropyridines with Analgesic, Antiinflammatory, and Hyperglycemic Activity
Yeung, Jupita M.,Corleto, Linda A.,Knaus, Edward E.
, p. 191 - 195 (2007/10/02)
A group of N-(carbonylamino)-1,2,3,6-tetrahydropyridines was synthesized to investigate the effects that changes in functionality at the carbonyl group have on analgesic, antiinflammatory, and hyperglycemic activities.One of the most active analgesic comp
