496865-78-2Relevant academic research and scientific papers
Convenient synthesis and evaluation of enzyme inhibitory activity of several N-alkyl-, N-phenylalkyl, and cyclic isourea derivatives of 5a-Carba-α-DL-fucopyranosylamine
Ogawa, Seiichiro,Mori, Makiko,Takeuchi, Goichi,Doi, Fuminao,Watanabe, Maiko,Sakata, Yuko
, p. 2811 - 2814 (2002)
Convenient synthesis and chemical modification of the potent α-L-fucosidase inhibitor, 5a-carba-α-DL-fucopyranosylamine (1), are described. Among seven N-substituted and three cyclic isourea derivatives newly prepared, the N-octyl derivative was found to be the strongest inhibitor of α-L-fucosidase (bovine kidney) more potent (Ki=0.016 μM) than deoxyfuconojirimycin (Ki=0.031 μM) with p-nitrophenyl-α-L-fucopyranoside as the substrate.
