496881-81-3

Basic information

• Product Name: Pentanoic acid, 5-amino-5-oxo-3-[[(phenylmethoxy)carbonyl](phenylmethyl)amino]-, methyl ester, (3S)-
• CAS NO: 496881-81-3
• Molecular Formula: C21H24N2O5
• Molecular Weight: 384.432
• Mol File: 496881-81-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pentanoic acid, 5-amino-5-oxo-3-[[(phenylmethoxy)carbonyl](phenylmethyl)amino]-, methyl ester, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 5-amino-5-oxo-3-[[(phenylmethoxy)carbonyl](phenylmethyl)amino]-, methyl ester, (3S)-(496881-81-3)
• EPA Substance Registry System: Pentanoic acid, 5-amino-5-oxo-3-[[(phenylmethoxy)carbonyl](phenylmethyl)amino]-, methyl ester, (3S)-(496881-81-3)

Safety Data

• Hazardous Substances Data: 496881-81-3(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 496881-80-2 methyl (S)-(-)-3-(benzylamino)-4-carbamoylbutanoate 
• 5164-76-1 dimethyl glutaconate 
• 109270-76-0 dimethyl 3-(benzylamino)pentanedioate 
• 100-46-9 benzylamine 

Relevant articles and documents

Synthesis of (R)-3,4-diaminobutanoic acid by desymmetrization of dimethyl 3-(benzylamino)glutarate through enzymatic ammonolysis

Lipase B from Candida antarctica is shown to be a highly efficient catalyst for the desymmetrization of dimethyl 3-(benzylamino)glutarate (1) through aminolysis and ammonolysis reactions. Using this procedure, enantiopure monoamides are obtained in high yield. The synthetic value of these compounds is demonstrated by the preparation of an enantiopure nonnatural amino acid, i.e. (R)-3,4-diaminobutanoic acid [(+)-12].