496916-54-2

Upstream product

• 21085-72-3 1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester 
• 496916-53-1 methyl {2-fluoro-4-[bis(2-hydroxyethyl)amino]phenyl 2,3,4-tri-O-acetyl-β-D-glucopyranosid}uronate 
• 496916-51-9 methyl (2-fluoro-4-nitrophenyl 2,3,4-tri-O-acetyl-β-D-glucopyranosid)uronate 
• 496916-52-0 methyl (2-fluoro-4-aminophenyl 2,3,4-tri-O-acetyl-β-D-glucopyranosid)uronate 
• 403-19-0 2-fluoro-4-nitrophenol 

Downstream Products

• 496916-56-4 2-fluoro-4-[bis(2-chloroethyl)amino]phenyl β-D-glucopyranosiduronic acid 
• 496916-55-3 methyl {2-fluoro-4-[bis(2-chloroethyl)amino]phenyl β-D-glucopyranosid}uronate 

Relevant academic research and scientific papers

In vitro fluorine-19 nuclear magnetic resonance study of the liberation of antitumor nitrogen mustard from prodrugs

The syntheses of two novel glucuronide prodrugs of nitrogen mustard with a fluorine tag are reported. These prodrugs, which differ only by the presence or not of a spacer, were designed for selective activation in the necrotic area of tumors by β-glucuron