496917-75-0Relevant academic research and scientific papers
Studies on the synthesis of kijanolide: Synthesis of an advanced seco-acid intermediate
Roush, William R.,Chen, Hou,Reilly, Melissa L.
, p. 259 - 282 (2007/10/03)
A synthesis of an advanced seco acid intermediate (7) in a projected total synthesis of kijanolide is described. Key steps in the synthesis of 7 include the highly diastereoselective allylation reaction of 15, the Suzuki cross coupling of dienyl iodide (11) and vinylboronic acid (12), and the IMDA reaction of 9. Elaboration of the spirotetronic acid unit of 7 was accomplished by a Dieckmann cyclization of the α-acetoxy ester intermediate derived from the IMDA cycloadduct (39).
