496925-70-3

Basic information

• Product Name: 1H-Imidazole-5-carboxaldehyde, 2-(methylthio)-1-[(4-nitrophenyl)methyl]-
• CAS NO: 496925-70-3
• Molecular Formula: C12H11N3O3S
• Molecular Weight: 277.304
• Mol File: 496925-70-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-5-carboxaldehyde, 2-(methylthio)-1-[(4-nitrophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-5-carboxaldehyde, 2-(methylthio)-1-[(4-nitrophenyl)methyl]-(496925-70-3)
• EPA Substance Registry System: 1H-Imidazole-5-carboxaldehyde, 2-(methylthio)-1-[(4-nitrophenyl)methyl]-(496925-70-3)

Safety Data

• Hazardous Substances Data: 496925-70-3(Hazardous Substances Data)

Upstream product

• 18600-42-5 4-nitrobenzylamine hydrochloride 
• 114772-19-9 1-(4-Nitrobenzyl)-2-Mercapto-5-Hydroxymethylimidazole 
• 114772-20-2 5-hydroxymethyl-2-methylthio-1-[(4-nitropehnyl)methyl]imidazole 

Relevant articles and documents

Synthesis and calcium antagonist activity of new 1,4-dihydropyridines containing nitrobenzylimidazolyl substituent in ginea-pig ileal smooth muscle

New alkyl ester analogues of nifedipine, in which the ortho-nitrophenyl group of position 4 is replaced by 1-(4-nitrobenzyl)-5-imidazolyl or 2-methylthio-1-(4-nitrobenzyl)-5-imidazolyl substituent, were synthesized and evaluated as calcium-channel antagonists using the electrically induced contraction of guinea-pig ileal longitudinal smooth muscle. Our results demonstrate that all compounds inhibited the contractile response of guinea-pig ileum to electrical stimulation and the IC50 value of the most potent compounds 6a and 6f were significantly lower than that of nifedipine. Therefore, they are more potent than nifedipine.