496931-63-6Relevant academic research and scientific papers
Synthesis and properties of substituted isoxazolo[3′,4′:4,5]- thieno[2,3-b]pyridines
Vasilin,Kaigorodova,Firgang,Krapivin
, p. 377 - 386 (2007/10/03)
We synthesized derivatives of a novel heterocyclic system, isoxazolo[3′,4′:4,5]thieno[2,3-b]pyridine by sequential conversions in three steps: isomerization of 2-(2-R-ethylthio-2-oxo)-3-pyridyl cyanides obtained by alkylation from substituted 3-cyano-2(1H)-pyridinethiones by α-halomethyl ketones in alkaline medium, to form 3-aminothieno[2,3-b] pyridines; diazotization of the amino group followed by nucleophilic substitution of the diazonium group by an azido group, bypassing the step of isolating the diazonium salts; and thermolysis of the azides formed.
