496932-75-3Relevant academic research and scientific papers
3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3β
Arnost, Michael,Pierce, Al,Haar, Ernst ter,Lauffer, David,Madden, Jaren,Tanner, Kirk,Green, Jeremy
experimental part, p. 1661 - 1664 (2010/07/03)
A series of 3-aryl-4-(arylhydrazono)-1H-pyrazol-5-one inhibitors of GSK3β was developed from a low molecular weight, highly ligand efficient screening hit 1. Hit-to-lead optimization led to a number of highly potent inhibitors, while maintaining the high ligand efficiency of the screening hit.
