497083-37-1

Basic information

• Product Name: ethyl 2-((5-chloro-2-methoxyphenyl)amino)thiazole-4-carboxylate
• Synonyms: ethyl 2-((5-chloro-2-methoxyphenyl)amino)thiazole-4-carboxylate
• CAS NO: 497083-37-1
• Molecular Weight: 312.777
• Mol File: 497083-37-1.mol

Chemical Properties

• CAS DataBase Reference: ethyl 2-((5-chloro-2-methoxyphenyl)amino)thiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-((5-chloro-2-methoxyphenyl)amino)thiazole-4-carboxylate(497083-37-1)
• EPA Substance Registry System: ethyl 2-((5-chloro-2-methoxyphenyl)amino)thiazole-4-carboxylate(497083-37-1)

Safety Data

• Hazardous Substances Data: 497083-37-1(Hazardous Substances Data)

Upstream product

• 70-23-5 ethyl Bromopyruvate 
• 63980-69-8 (2-methoxy-5-chlorophenyl)-2-thiourea 

Downstream Products

• 913651-35-1 2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carboxylic acid 
• 913650-38-1 2-[(5-chloro-2-hydroxyphenyl)amino]-1,3-thiazole-4-carboxylic acid 

Relevant articles and documents

Δf508-CFTR correctors: Synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles

The most common mutation causing cystic fibrosis (CF) is deletion of phenylalanine residue 508 in the cystic fibrosis transmembrane regulator conductance (CFTR) protein. Small molecules that are able to correct the misfolding of defective ΔF508-CFTR have considerable promise for therapy. Reported here are the design, preparation, and evaluation of five more hydrophilic bisazole analogs of previously identified bithiazole CF corrector 1. Interestingly, bisazole ΔF508-CFTR corrector activity was not increased by incorporation of more H-bond acceptors (O or N), but correlated best with the overall bisazole molecular geometry. The structure activity data, together with molecular modeling, suggested that active bisazole correctors adopt a U-shaped conformation, and that corrector activity depends on the molecule's ability to access this molecular geometry.