497154-90-2Relevant academic research and scientific papers
Synthesis of protected syn 1,3-diols by intramolecular conjugate addition to vinyl sulfones
Grimaud, Laurence,Rotulo, Delphine,Ros-Perez, Rafael,Guitry-Azam, Ludivine,Prunet, Jo?lle
, p. 7477 - 7479 (2002)
A short route to sulfones 9a-c is described. These synthons encompassing a syn 1,3-diol motif are model compounds for the C16-C24 fragment of Dolabelides. The benzylidene protecting group can be reduced regioselectively to furnish β-hydroxysulfones 10a-b. First attempts of Julia coupling of the dianions derived from these substrates with aldehydes and ketones are also reported.
