497165-55-6

Basic information

• Product Name: Pyridine, 2,3,5,6-tetrafluoro-4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-2H-1,2,3-triazol-2 -yl]-
• CAS NO: 497165-55-6
• Molecular Formula: C18H8F5N5
• Molecular Weight: 389.287
• Mol File: 497165-55-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyridine, 2,3,5,6-tetrafluoro-4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-2H-1,2,3-triazol-2 -yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2,3,5,6-tetrafluoro-4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-2H-1,2,3-triazol-2 -yl]-(497165-55-6)
• EPA Substance Registry System: Pyridine, 2,3,5,6-tetrafluoro-4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-2H-1,2,3-triazol-2 -yl]-(497165-55-6)

Safety Data

• Hazardous Substances Data: 497165-55-6(Hazardous Substances Data)

Upstream product

• 700-16-3 Pentafluoropyridine 
• 474511-81-4 4-[5-(4-fluoro-phenyl)-2H-[1,2,3]triazol-4-yl]-pyridine 
• 208105-22-0 1-(pyridin-4-yl)-2-(4-fluorophenyl)ethyne 

Relevant articles and documents

SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.

2,6-Diamino-3,5-difluoropyridinyl substituted pyridinylimidazoles, -pyrroles, -oxazoles, -thiazoles and -triazoles have been identified as novel p38alpha inhibitors. Pyridinylimidazole 11 potently inhibited LPS-induced TNFalpha in mice, showed good efficacy in the established rat adjuvant (ED(50): 10 mg/kg po b.i.d.) and collagen induced arthritis (ED(50): 5 mg/kg po b.i.d.) with disease modifying properties based on histological analysis of the joints.