497179-52-9 Usage
Aromatic heterocyclic compound with a five-membered ring
This describes the structure of the compound, which has a ring of five atoms with one nitrogen atom in it, giving it a distinctive aromatic smell.
Derivative of isoindolone
This indicates that the compound is derived from isoindolone, a parent compound from which it is synthesized.
Yellowish crystalline solid
This describes the physical appearance of the compound, which is a yellowish solid with a crystalline structure.
Insoluble in water, soluble in organic solvents
This indicates the solubility properties of the compound, which means it does not dissolve in water but dissolves in organic solvents.
Used as a building block for the synthesis of various compounds
This indicates the compound's use in the pharmaceutical and chemical industries as a starting material for the synthesis of other compounds.
Specific properties and potential uses still being studied and evaluated
This indicates that the compound's properties and potential uses are not yet fully understood and are still being researched.
Check Digit Verification of cas no
The CAS Registry Mumber 497179-52-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,7,1,7 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 497179-52:
(8*4)+(7*9)+(6*7)+(5*1)+(4*7)+(3*9)+(2*5)+(1*2)=209
209 % 10 = 9
So 497179-52-9 is a valid CAS Registry Number.
497179-52-9Relevant articles and documents
Investigation of the mechanism of C(sp3)-H bond cleavage in Pd(0)-catalyzed intramolecular alkane arylation adjacent to amides and sulfonamides
Rousseaux, Sophie,Gorelsky, Serge I.,Chung, Benjamin K. W.,Fagnou, Keith
supporting information; experimental part, p. 10692 - 10705 (2010/11/05)
The reactivity of C(sp3)-H bonds adjacent to a nitrogen atom can be tuned to allow intramolecular alkane arylation under Pd(0) catalysis. Diminishing the Lewis basicity of the nitrogen lone pair is crucial for this catalytic activity. A range of N-methylamides and sulfonamides react exclusively at primary C(sp3)-H bonds to afford the products of alkane arylation in good yields. The isolation of a Pd(II) reaction intermediate has enabled an evaluation of the reaction mechanism with a focus on the role of the bases in the C(sp3)-H bond cleaving step. The results of these stoichiometric studies, together with kinetic isotope effect experiments, provide rare experimental support for a concerted metalation-deprotonation (CMD) transition state, which has previously been proposed in alkane C(sp3)-H arylation. Moreover, DFT calculations have uncovered the additional role of the pivalate additive as a promoter of phosphine dissociation from the Pd(II) intermediate, enabling the CMD transition state. Finally, kinetic studies were performed, revealing the reaction rate expression and its relationship with the concentration of pivalate.
