497239-45-9

Usage

Uses

Used in Pharmaceutical Industry:
3-Oxetanemethanamine, 3-phenylis used as a building block for the synthesis of various pharmaceuticals and bioactive compounds. Its unique structure and properties make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry Research:
3-Oxetanemethanamine, 3-phenylis used as a research compound in medicinal chemistry to explore its pharmacological activities and potential applications in drug development. Its unique properties and interactions with biological systems make it an interesting candidate for further studies and research.

Upstream product

• 215719-41-8 2-(3-phenyloxetan-3-ylmethyl)isoindole-1,3-dione 
• 215719-44-1 (3-phenyl-oxetan-3-yl)methyl p-toluenesulfonate 
• 114012-43-0 (3-phenyl-oxetan-3-yl)methanol 
• 4704-99-8 α,α,α-tris(hydroxymethyl)toluene 

Downstream Products

• 497239-46-0 N-(3-phenyloxetan-3-ylmethyl)benzamide 

Relevant academic research and scientific papers

Unusual cyclodimerization of small cyclic ethers via neighboring carbonyl-group participation and cation transfer

Oxetanes having both a carbonyl functional group and a phenyl group at the 3-position bring about unusual cyclodimerization under the influence of trifluoromethanesulfonic acid, to give a cis/trans-isomer mixture of substituted 1,3-dioxanes via neighboring carbonyl-group participation, cation transfer including phenonium rearrangement, and cyclodimerization. Oxiranes having a carbonyl functional group also undergo a similar cyclodimerization to form a 1,3-dioxolane ring. No phenyl substituent is required in the cases of the oxiranes, because the cation transfer process involves a 1,2-hydride shift alone. These five- and six-membered cyclic acetals are quite different from ring-expanded cyclic ether dimers expected simply from the back-biting reaction known in the cationic ring-opening polymerization of oxiranes and oxetanes.