497258-69-2Relevant academic research and scientific papers
Nanomolar β-lactamase inhibitors
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Page/Page column 7; 34-35, (2010/11/28)
New carboxyphenyl-glycylboronic acid transition-state analog inhibitors, representative of a class of compounds effective against class C β-lactamase AmpC. The new compounds improve inhibition by over two-orders of magnitude compared to analogous glycylboronic acids, with Ki values as low as 1 nM.
Nanomolar inhibitors of AmpC β-lactamase
Morandi, Federica,Caselli, Emilia,Morandi, Stefania,Focia, Pamela J.,Blazquez, Jesus,Shoichet, Brian K.,Prati, Fabio
, p. 685 - 695 (2007/10/03)
β-lactamases are the most widespread resistance mechanism to β-lactam antibiotics, such as the penicillins and the cephalosporins. In an effort to combat these enzymes, a combination of stereoselective organic synthesis, enzymology, microbiology, and X-ra
