497261-38-8

Basic information

• Product Name: 8-BROMO-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE
• Synonyms: 8-BROMO-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE;AKOS JY2083411
• CAS NO: 497261-38-8
• Molecular Formula: C₁₁H₁₁BrN₂
• Molecular Weight: 251.12
• Mol File: 497261-38-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 8-BROMO-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMO-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE(497261-38-8)
• EPA Substance Registry System: 8-BROMO-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE(497261-38-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 497261-38-8(Hazardous Substances Data)

Usage

General Description

8-Bromo-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole is a chemical compound categorized under the class of organic compounds known as tetrahydroisoquinolines. Its chemical formula is C11H12BrN. 8-BROMO-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE is slightly soluble in water. It is a synthetic compound with potential uses in chemical research. As it is not widely studied, its exact properties, potential applications, and safety precautions are not entirely known. It should be handled with care following standard laboratory procedures.

Upstream product

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Relevant articles and documents

Design and synthesis of some novel 2,3,4,5-tetrahydro-1H-pyrido[4,3-b] indoles as potential c-Met inhibitors

Since deregulation of the tyrosine-kinase receptor c-Met is implicated in several human cancers and is an attractive target for small-molecule-drug discovery, we report herein the synthesis of 2,3,4,5-tetrahydro-8-[1-(quinolin- 6-ylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrido[4,3-b]indoles 4a-4c and 2,3,4,5-tetrahydro-8-[3-(quinolin-6-ylmethyl)-1,2,4-triazolo[4,3-b] pyridazin-6-yl]-1H-pyrido[4,3-b]indoles 5a-5c. These indole derivatives demonstrated inhibition of c-Met kinase activity. Concurrently, five key intermediates were synthesized. These compounds could be prepared in good yields. Copyright

Functionalized tetrahydro-1 H-pyrido[4,3-b]indoles: A novel chemotype with Sirtuin 2 inhibitory activity

Sirtuins are protein deacylases with regulatory roles in metabolism and stress response. Functionalized tetrahydro-1H-pyrido[4,3-b]indoles were identified as preferential sirtuin 2 inhibitors, with in vitro inhibitory potencies in the low micromolar conce

FUSED HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HISTONE DEACETYLASE

Disclosed are compounds of formula (I) that inhibit histone deacetylase (HDAC) enzymatic activity, pharmaceutical compositions comprising such compounds, as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC, wherein A, W, W1, W2, Ar2, and G are described herein.