497262-00-7

Upstream product

• 497261-97-9 (1R,8R)-8-(bromomethyl)-1,8-dimethyl-3-oxabicyclo[3.2.1]octane-2,4-dione 
• 497261-98-0 (1R,5R,8R)-8-(bromomethyl)-1,8-dimethyl-3-oxabicyclo[3.2.1]octane-2-one 
• 10293-09-1 (1R,4R,7R)-9-bromocamphor 
• 497261-96-8 (1R,7R)-7-(bromomethyl)-1,7-dimethylbicyclo[2.2.1]heptane-2,3-dione 
• 98-59-9 p-toluenesulfonyl chloride 
• 497261-99-1 (1R,2R,3S)-(2-bromomethyl-3-hydroxymethyl-2,3-dimethylcyclopentyl)methanol 

Downstream Products

• 1027594-31-5 2-{(1R,2R,3S)-2,3-Bis-[(diphenylphosphanyl)-methyl]-1,2-dimethyl-cyclopentylmethoxy}-tetrahydro-pyran 
• 497262-02-9 [(1R,2R,3S)-21,2-dimethyl-2,3-bis(diphenylphosphine-methyl)cyclopentyl]methanol 
• 497262-01-8 [(1R,2R,3S)-2-(bromomethyl)-2,3-dimethyl-3-[(tetrahydro-2H-pyran-2-yloxy)methyl]cyclopentyl]methyl-4-methylbenzenesulfonate 

Relevant academic research and scientific papers

A new hydroxydiphosphine as a ligand for Rh(I)-catalyzed enantioselective hydrogenation

A new diphosphine ligand bearing a hydroxy group in the backbone was synthesized starting from 9-bromocamphor. The rhodium(I) complex based on this ligand was tested in the hydrogenation of α- and β-amino acid precursors. The activity and selectivity of the catalyst were found to be strongly dependent upon the nature of the substrate. Thus, β-acetylamino carboxylates were obtained with up to 97% ee.

HYDROXY DIPHOSPHINES AND THEIR USE IN CATALYSIS

The invention relates to novel asymmetrical, chiral hydroxy diphosphines and to derivatives of general formula (I), in addition to their use as catalysts, in particular for enantioselective syntheses.