49747-52-6

Upstream product

• 108-86-1 bromobenzene 
• 82588-90-7 Methyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-methylenepropanoate 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 100-51-6 benzyl alcohol 
• 536-74-3 phenylacetylene 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 91-16-7 1,2-dimethoxybenzene 
• 151647-54-0 3-phenyl-1-pyrrolidin-1-yl-propane-1-one 
• 591-50-4 iodobenzene 
• 31706-95-3 1'-Hydroxymethyleugenol 
• 183303-74-4 1-(3,4-dimethoxyphenyl)-2-phenoxy-1-ethanol 
• 4087-66-5 (E)-3-(2-bromophenyl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one 
• 4087-66-5 1-(3,4-dimethoxyphenyl)-3-phenylprop-2-en-1-one 
• 53744-27-7 3,4-dimethoxychalcone 

Downstream Products

• 101878-37-9 1-(3,4-dimethoxy-phenyl)-3-phenyl-propane-1,2-dione-2-oxime 
• 52947-25-8 2-amino-1-(3,4-dimethoxy-phenyl)-3-phenyl-propan-1-ol 
• 49747-68-4 4-(1-chloro-3-phenyl-propyl)-1,2-dimethoxy-benzene 
• 49747-80-0 4-[1-(3,4-dimethoxy-phenyl)-3-phenyl-propyl]-morpholine 
• 49747-67-3 1-(3,4-Dimethoxy-phenyl)-3-phenyl-propan-1-ol 

Relevant academic research and scientific papers

Direct conversion of secondary propargyl alcohols into 1,3-di-arylpropanoneviaDBU promoted redox isomerization and palladium assisted chemoselective hydrogenation in a single pot operation

Palladium(ii)acetate is found to be an efficient catalyst for the single-step conversion of secondary propargyl alcohols to 1,3-diarylpropanone derivatives under mild basic conditions. The reaction is believed to proceedviaredox isomerisation of secondary propargyl alcohols followed by chemoselective reduction of an enone double bond with formic acid as an adequate hydrogen donor. A large number of 1,3-diarylpropanone derivatives may readily be prepared from a milligram to a multigram scale.

C?C Bond Formation of Benzyl Alcohols and Alkynes Using a Catalytic Amount of KOtBu: Unusual Regioselectivity through a Radical Mechanism

We report a C?C bond-forming reaction between benzyl alcohols and alkynes in the presence of a catalytic amount of KOtBu to form α-alkylated ketones in which the C=O group is located on the side derived from the alcohol. The reaction proceeds under thermal conditions (125 °C) and produces no waste, making the reaction highly atom efficient, environmentally benign, and sustainable. Based on our mechanistic investigations, we propose that the reaction proceeds through radical pathways.

New Friedel-Crafts strategy for preparing 3-acylindoles

A selective Friedel-Crafts acylation of indoles via an unusual cleavage of the amide C-N bond was achieved by triflic anhydride activation. This method offers rapid efficient access to high-biological-value 3-acylindoles, performs a series of scrupulous mechanistic studies and offers a strong courage that amide synthons can form new C-C bonds under transition-metal-free conditions.

Fabrication of Pd/CuFe2O4 hybrid nanowires: A heterogeneous catalyst for Heck couplings

The development of environmentally benign transformations is indispensable in organic synthesis. Herein, a hybrid heterogeneous catalyst, palladium(0) on copper ferrite nanowires, has been synthesized, characterized, and for the first time, employed in the Jeffrey Heck reaction between iodoarenes and allylic alcohols, and good to excellent yields have been obtained. In addition, the catalyst was found to be suitable for the usual Heck coupling. The nanocatalyst was recovered and reused up-to multiple runs without any noticeable loss of its catalytic activity.

[Pd]-Catalyzed Intermolecular Coupling and Acid Mediated Intramolecular Cyclodehydration: One-Pot Synthesis of Indenes

An efficient one-pot synthesis of indenes from simple starting materials is presented. This process involves a dual C–C bond formation through an intermolecular Heck coupling reaction followed by acid-mediated intramolecular cyclodehydration. The strategy

Efficient alkylation of ketones with primary alcohols catalyzed by ruthenium(II)/P,N ligand complexes

An efficient catalytic system containing [RuCl2(η6-p-cymene)]2 and one P,N ligand, N-diphenylphosphino-2-aminopyridine (L1) was loaded in catalyzing the alkylation of ketones with primary alcohols for a diverse array of substrates. Other five P,N ligands based on pyridin-2-amine and pyrimidin-2-amine were also examined in this reaction to explore the influence of steric hindrance and electronic effects. Monitoring by 1H NMR and ESI-MS reveals a stable cationic L1-coordinated ruthenium hydride intermediate, identified as [Ru(η6-p-cymene)(κ2-L1)H]+. Organic intermediates consistent with a three-step dehydrogenation, alkylation and hydrogenation pathway were also observed. The final step in this reaction, the ruthenium-catalysed transfer hydrogenation reduction of α,β-unsaturated ketone with benzyl alcohol was performed separately.

Efficient chemoselective biohydrogenation of 1,3-diaryl-2-propen-1-ones catalyzed by Saccharomyces cerevisiae yeasts in biphasic system

A series of chalcones (1-9) was synthesized by base catalyzed aldol condensation with 50-94% yields. These α,β-unsaturated carbonyl compounds were used as substrates in biotransformation reactions mediated by three industrial Saccharomyces cerevisiae strains in biphasic systems. Several reaction parameters were evaluated, such as yeast concentration, temperature, pH, substrate concentration, organic solvent, volume of aqueous and organic phases and the influence of substituent groups on chalcones 1-9. The biotransformation was chemoselective and formed only the corresponding saturated ketones. The highest conversion (>99%) to the dihydrochalcone was obtained at 30-45°C and pH above 5.5, while the cellular and substrate concentrations also showed a strong influence on the biohydrogenation reaction. Organic solvents with log. P >3.2 (hexane or heptane) were the most appropriate, and 40-80% of aqueous phase allowed the highest conversions probably by maintaining the yeast enzymes catalytically active. The influence of substituents on rings A and B of chalcones 1-9 was low and no correlation between the donor or withdrawing electron groups was observed.

Facile synthesis of 1, 3-diaryl-propanones through heck reaction

1,3-diaryl propanones (1a-6a) and 1,3-diaryl-2-carbomethoxypropanones (1b-6b) have been synthesized through facile palladium catalysed arylation of Baylis-Hillman adducts.