49759-88-8

Upstream product

• 1738-76-7 glycine benzyl ester p-toluenesulfonic acid salt 
• 2462-31-9 benzyl 2-aminoacetate hydrochloride 
• 4192-12-5 dicyclohexylammonium N-(tert-butoxycarbonyl)-L-phenylalaninate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 42280-29-5 [(S)-2-tert-butoxycarbonylamino-3-phenylpropanoylamino]acetic acid benzyl ester 

Downstream Products

• 90282-81-8 Boc-Gly-L-Phe-Gly-OBzl 
• 146875-09-4 [(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-3-phenyl-propionylamino]-acetic acid benzyl ester 
• 82487-57-8 Boc-D-Ala-Phe-Gly-OBzl 
• 82155-77-9 H-Phe-Phe-Gly-OBzl 
• 94991-05-6 Boc-Gln-Gln-Phe-Phe-Gly-Leu-Arg(NO₂)-OBzl 
• 94991-04-5 Boc-Gln-Gln-Phe-Phe-Gly-Leu-Arg(NO₂)-NH₂ 
• 83181-63-9 Boc-Gln-Gln-Phe=Phe-Gly-OBzl 
• 83181-64-0 Boc-Gln-Gln-Phe-Phe-Gly-OH 
• 64698-99-3 Boc-Gln-Phe-Phe-Gly-OBzl 
• 66638-61-7 H-Gln-Phe-Phe-Gly-OBzl 
• 90296-95-0 C₄₆H₅₇N₁₁O₁₂ 
• 90296-93-8 (S)-2-[(S)-2-({[(S)-1-(Benzyloxycarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 765856-18-6 [(S)-2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-acetic acid benzyl ester 

Relevant academic research and scientific papers

Gram-Scale Synthesis of a Hexapeptide by Fragment Coupling in a Ball Mill

Synthesis of long peptides is generally considered as a challenge to peptide chemists, in addition to producing significant amounts of toxic waste, such as DMF. Here we show that using solvent-less methods, such as ball milling, enabled the production of

Macrocyclization of biaryl-bridged peptides through late-stage palladium-catalyzed C(sp2)-H Arylation

Macrocyclic peptides are promising scaffolds of bioactive compounds and clinical therapeutics. Herein, we develop a strategy for the macrocyclization of biaryl-bridged peptides through late-stage Pd-catalyzed C(sp2)-H arylation. This method dis

Synthesis, binding affinities and metabolic stability of dimeric dermorphin analogs modified with β3-homo-amino acids

In this study, proteinogenic amino acids residues of dimeric dermorphin pentapeptides were replaced by the corresponding β3-homo-amino acids. The potency and selectivity of hybrid α/β dimeric dermorphin pentapeptides were evaluated by competeti

Kinetic studies on oxidation of Gly-Val-Gly, Gly-Phe-Ply and Ala-Val-Gly using Mn(III)

The fragments of elastin sequences, glycyl-valyl-glycine (GVG), glycyl-phenylalanyl-glycine (GFG) and alanyl-valyl-glycine (AVG) have been synthesized by classical solution phase method and characterized. Kinetics of oxidation of these tripeptides (TP) by Mn(III) has been studied in the presence of sulphate ions in acidic medium at 25°C. The reaction follows spectrophotometrically at Λmax 500 nm. A first order dependence of rate on both [Mn(III)] and [TP] has been observed. The rate is independent of concentrations of reduction product, Mn(II) and hydrogen ions. Effects of varying dielectric constant of the medium and addition of anions such as sulphate, chloride and perchlorate have been studied. Activation parameters have been evaluated using Arrhenius and Erying plots. The oxidation products are isolated and characterized. A tentative mechanism involving the reaction of TP with Mn(III) in the rate-limiting step is suggested. The effect of hydrophobicity of amino acids on the rate of oxidation is discussed.

Synthesis of immunoaduvant conjugates with HIV-derived peptide inducing peptide-specific antibody

MDP and lipopeptide analog conjugates inducing HIV-derived peptide-specific antibody without adding further macromolecular carriers or adjuvants were synthesized.

Studies of Bitter Peptides from Casein Hydrolyzate. IV. Relationship between Bitterness and Hydrophobic Amino Acids Moiety in the C-Terminal of BPIa (Arg-Gly-Pro-Pro-Phe-Ile-Val)

In the synthetic studies of bitter peptide BPIa (Arg-Gly-Pro-Pro-Phe-Ile-Val), we sythesized several BPIa analogs to elucidate the participation of the hydrophobic amino acids moiety in the C-terminal in the bitter taste exhibited by BPIa.The syntheses of