49762-56-3

Upstream product

• 6686-83-5 Z-Pro-Ile-Gly-OEt 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 50912-71-5 ((2S,3S)-2-Amino-3-methyl-pentanoylamino)-acetic acid ethyl ester; hydrochloride 
• 105414-01-5 Cbz-L-Pro-OCO₂-i-Bu 
• 66866-47-5 Boc-Ile-O-COOiBu 
• 56439-59-9 2-((2S,3S)-2-((tert-butoxycarbonyl)amino)-3-methylpentanamido)acetic aid ethyl ester 
• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of Analogues of Pro-Leu-Gly-NH2 Modified at the Leucyl Residue

A series of analogues of Pro-Leu-Gly-NH2 (PLG) in which the leucine residue has been replaced with the aliphatic amino acids L-isoleucine, L-2-aminohexanoic acid (Ahx), L-2-aminopentanoic acid, and L-2-aminobutanoic acid and the aromatic amino acids L-phenylalanine, L-phenylglycine, L- and D-2-amino-4-phenylbutanoic acid, L-O-methyltyrosine, and L-4-nitrophenylalanine have been synthesized.These analogues were tested for their ability to enhance the binding of the dopamine receptor agonist 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN) to striatal dopamine receptors.Two of the abov e analogues, Pro-Ahx-Gly-NH2 (3) and Pro-Phe-Gly-NH2 (6), showed significant activity in this assay system.Pro-Ahx-Gly-NH2 produced a 16percent enhancement of ADTN binding at 0.1 μM, while Pro-Phe-Gly-NH2 enhanced the binding of ADTN by 31percent at a concentration of 1 μM.