49764-30-9

Usage

Uses

Used in Fluorescent Dyes:
2,3-dimethyl-6H-indolo[2,3-b]quinoxaline is used as a fluorescent dye in various applications, such as in the detection and imaging of biological molecules, due to its ability to emit light upon excitation.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,3-dimethyl-6H-indolo[2,3-b]quinoxaline is used as a potential drug candidate for its demonstrated cytotoxic effects on certain cancer cell lines. Its pharmacological activities are being studied for the development of novel therapeutic agents.
Used in Organic Electronics:
2,3-dimethyl-6H-indolo[2,3-b]quinoxaline is also being investigated for its potential use in organic electronics, such as in the development of organic light-emitting diodes (OLEDs) and organic field-effect transistors (OFETs), due to its good charge transport properties.
However, it is important to note that the potential health and environmental impacts of 2,3-dimethyl-6H-indolo[2,3-b]quinoxaline are still being studied, and caution should be exercised in its use and handling to ensure safety and minimize any adverse effects.

Upstream product

• 91-56-5 indole-2,3-dione 
• 3171-45-7 4,5-dimethyl-1,2-phenylenediamine 
• 6972-71-0 4,5-dimethyl-2-nitrobenzenamine 

Downstream Products

• 112228-65-6 2,3-dimethyl-6-(N,N-dimethylaminoethyl)-6H-indolo(2,3-b)quinoxaline 

Relevant academic research and scientific papers

Interactions of antiviral indolo[2,3-b]quinoxaline derivatives with DNA

Here, we present the synthesis of five novel indoloquinoxaline derivatives and investigate the DNA binding properties of these monomeric as well as dimeric compounds using absorption, fluorescence, and linear dichroism. Several of the mono- and dicationic derivatives presented have previously demonstrated an excellent antiviral effect that is higher than already acknowledged agents against human cytomegalovirus (CMV), herpes simplex virus type 1 (HSV-1), and varicella-zoster virus (VZV). We find that the DNA binding constants of the monomeric and dimeric derivatives are high (～106) and very high (～109), respectively. Results from the spectroscopic measurements show that the planar aromatic indoloquinoxaline moieties upon interaction with DNA intercalate between the nucleobases. Furthermore, we use poly(dAdT) 2 and calf thymus DNA in a competitive binding experiment to show that all our derivatives have an AT-region preference. The findings are important in the understanding of the antiviral effect of these derivatives and give invaluable information for the future optimization of the DNA binding properties of this kind of drugs.

Alkylation of 5- and 6-methylindolo[2,3-b]quinoxalines: Revised structures of the N,N′-dimethylated salts

N,N'-Dialkylation of indolo[2,3-b]quinoxaline could theoretically furnish three isomers, that is, salts dialkylated at the 5,6-, the 6,11-, and the 5,11-positions. By using the 2,3-dimethylated derivatives as models, the regioisomeric salts were selective