49769-60-0

Usage

Uses

Used in Pharmaceutical Industry:
Alpha-hydroxypyridine-3-acetic acid is used as a starting material for the synthesis of enzimidazolylazabicyclooctylethylpiperidine Ccr5 antagonists. These antagonists play a crucial role in the treatment of bacterial and viral infections, as well as other diseases. alpha-hydroxypyridine-3-acetic acid's ability to serve as a building block for these therapeutic agents highlights its importance in the development of new medications to combat various health issues.

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 62-76-0 sodium oxalate 

Downstream Products

• 1373945-56-2 C₁₃H₁₀F₂N₂O₂ 
• 1373945-18-6 C₁₃H₈F₂N₂O₂ 
• 1373945-80-2 C₂₃H₁₈F₂N₄O 
• 1373945-66-4 C₂₂H₁₆F₂N₄O 

Relevant academic research and scientific papers

Oxalyl-CoA Decarboxylase Enables Nucleophilic One-Carbon Extension of Aldehydes to Chiral α-Hydroxy Acids

The synthesis of complex molecules from simple, renewable carbon units is the goal of a sustainable economy. Here we explored the biocatalytic potential of the thiamine-diphosphate-dependent (ThDP) oxalyl-CoA decarboxylase (OXC)/2-hydroxyacyl-CoA lyase (HACL) superfamily that naturally catalyzes the shortening of acyl-CoA thioester substrates through the release of the C1-unit formyl-CoA. We show that the OXC/HACL superfamily contains promiscuous members that can be reversed to perform nucleophilic C1-extensions of various aldehydes to yield the corresponding 2-hydroxyacyl-CoA thioesters. We improved the catalytic properties of Methylorubrum extorquens OXC by rational enzyme engineering and combined it with two newly described enzymes—a specific oxalyl-CoA synthetase and a 2-hydroxyacyl-CoA thioesterase. This enzymatic cascade enabled continuous conversion of oxalate and aromatic aldehydes into valuable (S)-α-hydroxy acids with enantiomeric excess up to 99 %.

DICARBONYLIC COMPOUNDS WITH ANTIBACTERIAL ACTIVITY

Compounds of formula (I), and their pharmaceutically acceptable salts and solvates, wherein X represents -O-, -NH-, -S-, -NHC(=O)- or -NHC(=S)-; R1 represents -H or a hydrocarbon chain; R2 represents -H, alkoxy, amino, a hydrocarbon chain or a radical of a cycle; R3 represents -H, a hydrocarbon chain or a radical of a cycle; R4 represents -H or a hydrocarbon chain; alternatively R3 and R4 form together a cycle; R5 and R6 represent -H or halogen, and R7 represents -H, a hydrocarbon chain or heteroaryl, are useful against bacterial infections in animals, including humans.