49779-95-5

Basic information

• Product Name: [4-(4-chlorophenyl)-2-(phenylamino)-1,3-thiazol-5-yl]acetic acid
• CAS NO: 49779-95-5
• Molecular Formula: C₁₇H₁₃ClN₂O₂S
• Molecular Weight: 344.8153
• Mol File: 49779-95-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 568.8°C at 760 mmHg
• Flash Point: 297.8°C
• Density: 1.419g/cm³
• Vapor Pressure: 8.87E-14mmHg at 25°C
• Refractive Index: 1.688
• CAS DataBase Reference: [4-(4-chlorophenyl)-2-(phenylamino)-1,3-thiazol-5-yl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(4-chlorophenyl)-2-(phenylamino)-1,3-thiazol-5-yl]acetic acid(49779-95-5)
• EPA Substance Registry System: [4-(4-chlorophenyl)-2-(phenylamino)-1,3-thiazol-5-yl]acetic acid(49779-95-5)

Safety Data

• Hazardous Substances Data: 49779-95-5(Hazardous Substances Data)

Upstream product

• 35158-39-5 3-bromo-3-(4-chlorobenzoyl)propionic acid 
• 103-85-5 monophenylthiourea 
• 49779-91-1 ethyl (2-N-phenylamino-4-p-chlorophenyl-thiazol-5-yl)acetate 

Relevant articles and documents

Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1

Structure-activity relationships of three related series of 4-phenylthiazol-5-ylacetic acids, derived from two hits emanating from a focused library obtained by in silico screening, have been explored as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) antagonists. Several compounds with double digit nanomolar binding affinity and full antagonistic efficacy for human CRTH2 receptor were obtained in all subclasses. The most potent compound was [2-(4-chloro-benzyl)-4-(4-phenoxy-phenyl)-thiazol-5-yl]acetic acid having an binding affinity of 3.7 nM and functional antagonistic effect of 66 nM in a BRET and 12 nM in a cAMP assay with no functional activity for the other PGD2 DP receptor (27 μM in cAMP).

5-Substituted 2-amino-4-arylthiazoles

5-Substituted 2-amino-4-arylthiazoles have interesting properties as anti-inflammatories, antipyretics, analgesics, antibacterials, C.N.S. depressants, anti-ulcer, and anti-cough agents.