49780-08-7

Basic information

• Product Name: 3-BROMO-4-(4-FLUOROPHENYL)-4-OXOBUTANOIC ACID
• Synonyms: 3-BROMO-4-(4-FLUOROPHENYL)-4-OXOBUTANOIC ACID;AKOS BBS-00001444
• CAS NO: 49780-08-7
• Molecular Formula: C₁₀H₈BrFO₃
• Molecular Weight: 275.07
• Mol File: 49780-08-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 384.6±37.0 °C(Predicted)
• Appearance: /
• Density: 1.653±0.06 g/cm3(Predicted)
• PKA: 3.71±0.19(Predicted)
• CAS DataBase Reference: 3-BROMO-4-(4-FLUOROPHENYL)-4-OXOBUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-(4-FLUOROPHENYL)-4-OXOBUTANOIC ACID(49780-08-7)
• EPA Substance Registry System: 3-BROMO-4-(4-FLUOROPHENYL)-4-OXOBUTANOIC ACID(49780-08-7)

Safety Data

• Hazardous Substances Data: 49780-08-7(Hazardous Substances Data)

Upstream product

• 366-77-8 4-(4-fluorophenyl)-4-oxopropionic acid 

Downstream Products

• 53515-06-3 [2-(4-bromo-phenyl)-4-(4-fluoro-phenyl)-thiazol-5-yl]-acetic acid 
• 459793-32-9 C₁₇H₁₂ClFN₂O₂S 
• 1214888-59-1 C₁₈H₁₄FNO₂S 
• 506437-09-8 C₁₇H₁₃FN₂O₂S 
• 1000959-60-3 C₁₈H₁₅FN₂O₃S 
• 870862-02-5 C₂₅H₁₈FNO₄S 
• 870862-04-7 C₂₅H₁₇F₄NO₃S 
• 870862-01-4 C₂₅H₂₀FNO₃S 
• 870861-97-5 C₂₅H₂₀FNO₃S 
• 870862-00-3 C₂₅H₂₀FNO₃S 
• 870862-03-6 C₂₅H₁₇FN₂O₂S 
• 870861-98-6 C₂₅H₁₇FN₂O₂S 
• 870861-96-4 C₂₄H₁₈FNO₂S 
• 870862-18-3 C₁₈H₁₃BrFNO₂S 

Relevant articles and documents

INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE

Compounds and salts thereof which are acyl-sulfonamides or certain carboxylic acids and which inhibit microbial growth or attenuate the virulence of pathogenic microorganisms and which inhibit UDP-galactopyranose mutase (UGM). Compounds of the invention include 2-aminothiazoles and triazolothiadiazines, particularly 3,6,7-substituted-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines, and 2-amino and salts thereof. Methods for inhibiting growth or attenuating virulence of microbial pathogens including mycobacterium, for example, M. tuberculosis and M. smegmatis and Klebsiella, for example, Klebsiella pneumoniae. Methods for inhibiting eukaryotic human and animal pathogens, and fungi and nematodes in particular. Methods for treatment of infections by prokaryotic and eukaryotic pathogens employing compounds of the invention.

AMINO-SUBSTITUTED AZO-HETEROCYCLIC COMPOUNDS FOR TREATING INFLAMMATORY CONDITIONS

Compounds of formula (I) are CRTH2 antagonists, useful in the treatment of inflammatory, autoimmune, respiratory or allergy disease: wherein X1 is -S-, -O-, -N=N-. -NR5-, -CR5=CR6-, -CR5=N-, wherein R5 and R6 are independently hydrogen or C1-C3 alkyl; R1 is hydrogen or C1-C3 alkyl or cyclopropyl; R2 is an optionally substituted phenyl or 5- or 6-membered monocyclic heteroaryl ring; R3 is an optionally substituted carbocyclic ring of 3 to 7 ring atoms, or an optionally substituted 4-, 5- or 6-membered monocyclic heterocyclic ring; R4 is a group other than hydrogen, methyl or ethyl of formula Q-[Alk1]m-[X]n-[Alk2]p-[Z}s- wherein m, n p, and s are independently 0 or 1 ; Q is hydrogen or an optionally substituted 4-, 5- or 6-membered monocyclic heterocyclic ring; Alk1 and Alk2 are independently optionally substituted C1-C3 alkylene radicals; X is -O-, -S-, -C(=O)-, - S(=O)-, -S(=O)2-, -CH(R7)-, -N(R7)-, or, in either orientation -SO2N(R7)- or - C(=O)N(R7)-, wherein R7 is hydrogen, or R7 represents a C2-C4 bridge between the C or N atom of X to which it is attached and a carbon atom of Alk2 and Z is -CH2, - C(=O) or -S(=O)2.

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This disclosure describes novel substituted ω-aroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.