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CAS

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49781-71-7

4-benzylamino-2-oxo-2,5-dihydro-pyrano[3,2-b]indole-3-carbonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 49781-71-7 Structure

  • Basic information

    1. Product Name: 4-benzylamino-2-oxo-2,5-dihydro-pyrano[3,2-b]indole-3-carbonitrile
    2. Synonyms:
    3. CAS NO:49781-71-7
    4. Molecular Formula:
    5. Molecular Weight: 315.331
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 49781-71-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-benzylamino-2-oxo-2,5-dihydro-pyrano[3,2-b]indole-3-carbonitrile(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-benzylamino-2-oxo-2,5-dihydro-pyrano[3,2-b]indole-3-carbonitrile(49781-71-7)
    11. EPA Substance Registry System: 4-benzylamino-2-oxo-2,5-dihydro-pyrano[3,2-b]indole-3-carbonitrile(49781-71-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 49781-71-7(Hazardous Substances Data)

49781-71-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 49781-71-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,9,7,8 and 1 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 49781-71:
(7*4)+(6*9)+(5*7)+(4*8)+(3*1)+(2*7)+(1*1)=167
167 % 10 = 7
So 49781-71-7 is a valid CAS Registry Number.

49781-71-7Downstream Products

49781-71-7Relevant articles and documents

Design and Synthesis of Pyrano[3,2-b]indolones Showing Antimycobacterial Activity

Monakhova, Natalia,Korduláková, Jana,Vocat, Anthony,Egorova, Anna,Lepioshkin, Alexander,Salina, Elena G.,Nosek, Jozef,Repková, Eva,Zemanová, Júlia,Jurdáková, Helena,Górová, Renáta,Roh, Jaroslav,Degiacomi, Giulia,Sammartino, José Camilla,Pasca, Maria Rosalia,Cole, Stewart T.,Miku?ová, Katarína,Makarov, Vadim

, p. 88 - 100 (2021)

Latent Mycobacterium tuberculosis infection presents one of the largest challenges for tuberculosis control and novel antimycobacterial drug development. A series of pyrano[3,2-b]indolone-based compounds was designed and synthesized via an original eight-step scheme. The synthesized compounds were evaluated for their in vitro activity against M. tuberculosis strains H37Rv and streptomycin-starved 18b (SS18b), representing models for replicating and nonreplicating mycobacteria, respectively. Compound 10a exhibited good activity with MIC99 values of 0.3 and 0.4 μg/mL against H37Rv and SS18b, respectively, as well as low toxicity, acceptable intracellular activity, and satisfactory metabolic stability and was selected as the lead compound for further studies. An analysis of 10a-resistant M. bovis mutants disclosed a cross-resistance with pretomanid and altered relative amounts of different forms of cofactor F420 in these strains. Complementation experiments showed that F420-dependent glucose-6-phosphate dehydrogenase and the synthesis of mature F420 were important for 10a activity. Overall these studies revealed 10a to be a prodrug that is activated by an unknown F420-dependent enzyme in mycobacteria.

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