497820-63-0Relevant academic research and scientific papers
SYNTHESIS OF (+-)-BIOTIN FROM A SUBSTITUTED 2,3-DEHYDROTHIOPHANE
Mikhano, S. D.,Kulachkina, N. S.,Filippova, T. M.,Suchkova, I. G.,Berezovskii, V. M.
, p. 176 - 178 (2007/10/02)
(+-)-Biotin has been synthesized from a mixture of cis- and allo-trisubstituted dehydrothiophanes by a scheme providing for the easy elimination of the accompanying allo-substituted thiophane in the form of an intermediate and not as the final isomeric allo-biotin.The imidazoline ring of biotin is formed from a dialkoxycarbonyldiaminothiophane under the conditions of partial hydrolysis of one of the protective groups with the elimination of phosgene from the scheme of synthesis.
