497831-75-1

Basic information

• Product Name: C₄₉H₇₈N₂O₁₂
• Synonyms: C₄₉H₇₈N₂O₁₂
• CAS NO: 497831-75-1
• Molecular Weight: 887.165
• Mol File: 497831-75-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₉H₇₈N₂O₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₉H₇₈N₂O₁₂(497831-75-1)
• EPA Substance Registry System: C₄₉H₇₈N₂O₁₂(497831-75-1)

Safety Data

• Hazardous Substances Data: 497831-75-1(Hazardous Substances Data)

Upstream product

• 131791-18-9 9(S)-hydroxy-6-O-methylerythromycin A 
• 497832-27-6 2',4,9(S)-triethylsilane-6-O-methylerythromycin A 
• 497832-30-1 C₆₂H₁₁₈N₂O₁₂Si₃ 

Relevant articles and documents

Synthesis and structure-activity relationship of a novel class of 15-membered macrolide antibiotics known as '11a-azalides'

Macrolide antibiotics are widely prescribed for the treatment of respiratory tract infections; however, the increasing prevalence of macrolide-resistant pathogens is a public health concern. Therefore, the development of new macrolide scaffolds with activities against resistant pathogens is urgently needed. An efficient method for reconstructing the erythromycin A macrolactone skeleton has been established. Based on this methodology, novel 15-membered macrolides, known as '11a-azalides', with substituents at the C12, C13, or C4″ positions were synthesized and their antibacterial activities were evaluated. These derivatives showed promising antibacterial activities against erythromycin-resistant Streptococcus pneumoniae. Among them, the C4″ substituted derivatives had the most potent activity against erythromycin-resistant S. pneumoniae.