497843-23-9Relevant academic research and scientific papers
Design and synthesis of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors. Part 3: In vitro evaluation of 1,3,4,5-Tetrahydro-benzo[c][1,6]- and [c][1,7]-naphthyridin-6-ones
Ferraris, Dana,Ficco, Rica Pargas,Pahutski, Thomas,Lautar, Susan,Huang, Shirley,Zhang, Jie,Kalish, Vincent
, p. 2513 - 2518 (2003)
The 1,3,4,5-tetrahydro-benzo[c][1,6]- and [c][1,7]-napthyridin-6-ones are presented as a potent class of PARP-1 inhibitors. Derivatives of these partially saturated aza-5[H]-phenanthridin-6-ones were designed and synthesized with tertiary amines for salt
