497847-05-9Relevant academic research and scientific papers
β-amino-α-hydroxy esters by asymmetric hydroxylation of homo-β-amino acid esters
Caputo, Romualdo,Cecere, Giuseppe,Guaragna, Annalisa,Palumbo, Giovanni,Pedatella, Silvana
, p. 3050 - 3054 (2007/10/03)
The asymmetric α-hydroxylation of N,N-diprotected homo-β-amino acid methyl esters is reported. The starting compounds are readily available, being prepared from simple α-amino acids by a procedure that we have already reported. α-Hydroxylation proceeded smoothly at -78°C with high yields and good diastereomeric ratios. In comparison with other asymmetric α-hydroxylation procedures, (a) this method does not need the use of costly chiral reagents and/or chiral auxiliaries and (b) it represents the first example of a procedure affording β-amino-α-hydroxy acids with full, orthogonal protection. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
