49786-02-9

Basic information

• Product Name: 2,4(1H,3H)-pyrimidinedione, 6-ethyl-1,3-dimethyl-
• Synonyms: 6-Ethyl-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 49786-02-9
• Molecular Formula: C₈H₁₂N₂O₂
• Molecular Weight: 168.1931
• Mol File: 49786-02-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 240.73°C at 760 mmHg
• Flash Point: 94.765°C
• Density: 1.118g/cm³
• Vapor Pressure: 0.037mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: 2,4(1H,3H)-pyrimidinedione, 6-ethyl-1,3-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-pyrimidinedione, 6-ethyl-1,3-dimethyl-(49786-02-9)
• EPA Substance Registry System: 2,4(1H,3H)-pyrimidinedione, 6-ethyl-1,3-dimethyl-(49786-02-9)

Safety Data

• Hazardous Substances Data: 49786-02-9(Hazardous Substances Data)

Upstream product

• 13509-52-9 1,3,6-trimethyluracil 
• 74-88-4 methyl iodide 
• 49846-86-8 6-cyano-1,3-dimethyluracil 
• 925-90-6 ethylmagnesium bromide 
• 82959-65-7 8-chloro-4,6-dimethyl-4,6-diazaspiro<2.5>octa-5,7-dione 

Relevant articles and documents

Synthesis of 6-alkyluridines from 6-cyanouridine via zinc(II) chloride-catalyzed nucleophilic substitution with alkyl grignard reagents

6-Cyanouracil derivatives underwent a direct nucleophilic substitution reaction with alkyl Grignard reagents in the presence of zinc(II) chloride as a catalyst to form the corresponding 6-alkyluracils. This methodology is applicable to sugar-protected 6-cyanouridine and 6-cyano-2′-deoxyuridine without the protection at the N3-imide and provides a facile and general access to versatile 6-alkyluracil and 6-alkyluridine derivatives.

Cycloaromatization of α-oxoketene dithioacetals with enaminone derived carbanions

Lithium enolates 3b and 6b derived from 1,3,6-trimethyluracil (3a) and 3-pyrrolidinocrotonate (6a) undergo regioselective γ-1,4- and γ-1,2-additions respectively with α-oxoketene dithioacetals 7 to yield the corresponding quinazolines and amino substituted aromatic compounds after subsequent cycloaromatization.