497866-82-7

Basic information

• Product Name: Oxazole, 2-benzo[b]thien-3-yl-4,5-dihydro-4-phenyl-, (4S)-
• CAS NO: 497866-82-7
• Molecular Formula: C17H13NOS
• Molecular Weight: 279.362
• Mol File: 497866-82-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Oxazole, 2-benzo[b]thien-3-yl-4,5-dihydro-4-phenyl-, (4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 2-benzo[b]thien-3-yl-4,5-dihydro-4-phenyl-, (4S)-(497866-82-7)
• EPA Substance Registry System: Oxazole, 2-benzo[b]thien-3-yl-4,5-dihydro-4-phenyl-, (4S)-(497866-82-7)

Safety Data

• Hazardous Substances Data: 497866-82-7(Hazardous Substances Data)

Upstream product

• 5381-25-9 benzo[b]thiophene-3-carboxylic acid 
• 20989-17-7 (2S)-2-phenylglycinol 
• 39827-12-8 benzothiophene-3-carbonyl chloride 
• 497866-74-7 benzo[b]thiophene-3-carboxylic acid (2-hydroxy-1-phenyl-ethyl)-amide 

Relevant articles and documents

The Application of HETPHOX Ligands to the Asymmetric Intermolecular Heck Reaction

Two new heterocyclic diphenylphosphinooxazolines derived from thiophene and benzothiophene were prepared in moderate to good yield and these, and a range of related HETPHOX ligands, were applied in the intermolecular asymmetric Heck reaction. Phenylation of 2,3-dihydrofuran with the t-butyl-substituted thiophene-oxazoline ligand gave (R)-2-phenyl-2,3-dihydrofuran highly regioselectively with excellent enantioselectivity (91-95% ee) and in good yields (70-97%). In addition, cyclohexenylation of 2,3-dihydrofuran proceeded with enantioselectivities of up to 97% ee in excellent (97%) yields, again with the t-butyl-substituted thiophene-oxazoline ligand proving optimal over a range of reaction conditions investigated.