497937-79-8

Upstream product

• 67069-59-4 N-methyl-[(1S,2R)-(2-phenyl-1-methyl-2-trimethylsilyloxy)]ethylamine 
• 41804-89-1 potassium triflinate 
• 299-42-3 ephedrine 

Downstream Products

• 118143-24-1 2,2,2-trifluoro-1,1-diphenyl-1-(trimethylsilyloxy)ethane 
• 208331-51-5 (E,E)-3-trifluoromethyl-3-trimethylsilyloxy-1,5-diphenyl-1,4-pentadiene 
• 124898-12-0 trimethyl[(2,2,2-trifluoro-1-phenylethoxy)]silane 
• 208331-49-1 (E)-trimethyl((1,1,1-trifluoro-2,4-diphenylbut-3-en-2-yl)oxy)silane 
• 228123-22-6 trimethyl-(2,2,2-trifluoro-1-methyl-1-phenyl-ethoxy)-silane 
• 228123-21-5 trimethyl[[(2E)-3-phenyl-1-(trifluoromethyl)-2-propenyl]oxy]silane 

Relevant academic research and scientific papers

Towards enantioselective nucleophilic trifluoromethylation

Various trifluoroacetamides and trifluoromethanesulfinamides, derived from chiral silylated amino alcohols, have been synthesized with the goal of achieving enantioselective nucleophilic trifluoromethylation. The best results were obtained with (R)-phenylglycinol derivatives, but the ee values did not exceed 30%.

Trifluoromethanesulfinamide from ephedrine: A more efficient trifluoromethylating reagent

Nucleophilic trifluoromethylation of non-enolizable and enolizable carbonyl compounds was achieved with the trifluoromethanesulfinamide derived from O-silylated ephedrine. In contrast to the trifluoroacetamide analog, previously described, this reagent is able to trifluoromethylate more acidic enolizable compounds.