497967-47-2Relevant academic research and scientific papers
Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.
-
, (2018/10/03)
PROBLEM TO BE SOLVED: To provide ligands for the nicotinic α-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.
QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
-
, (2011/05/11)
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
-
Page/Page column 89, (2009/10/31)
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
Reductive decyanation of pyrazinecarbonitriles
Albaneze-Walker, Jennifer,Zhao, Matthew,Baker, Melinda D,Dormer, Peter G,McNamara, James
, p. 6747 - 6750 (2007/10/03)
Pyrazinecarbonitriles can be decyanated by hydrogenation with platinum on carbon in the presence of activated carbon under acidic conditions. Pyrazine carbonitrile-N-oxides undergo a stepwise reduction to the deoxy-pyrazinecarbonitriles followed by decyan
