4980-30-7

Upstream product

• 140-87-4 Cyanoacetohydrazide 
• 104-88-1 4-chlorobenzaldehyde 
• 19411-75-7 3-(4-chlorobenzylidene)pentane-2,4-dione 

Downstream Products

• 1193089-16-5 2-amino-N'-[(4-chlorophenyl)methylene]-5-oxo-5H-chromeno[2,3-b]pyridine-3-carbohydrazide 
• 1235885-43-4 C₂₃H₁₄ClN₃O 
• 1380529-56-5 dimethyl 1-(4-chlorobenzylideneamino)-5-cyano-4-(cyclohexylamino)-6-oxo-1,2,5,6-tetrahydropyridine-2,3-dicarboxylate 
• 1380529-08-7 dimethyl 1-(4-chlorobenzylideneamino)-5-cyano-4-(2-ethoxy-2-oxoethylamino)-6-oxo-1,2,5,6-tetrahydropyridine-2,3-dicarboxylate 
• 1426561-99-0 4-chlorobenzaldehyde N-[1-(4-acetylphenyl)-3-acetyl-4-cyanopyrazol-5-yl]hydrazone 
• 1426561-95-6 4-chlorobenzaldehyde N-[1-phenyl-3-acetyl-4-cyanopyrazol-5-yl]hydrazone 
• 1426561-96-7 4-chlorobenzaldehyde N-[1-(4-methylphenyl)-3-acetyl-4-cyanopyrazol-5-yl]hydrazone 
• 1426561-97-8 4-chlorobenzaldehyde N-[1-(4-chlorophenyl)-3-acetyl-4-cyanopyrazol-5-yl]hydrazone 
• 1426561-98-9 4-chlorobenzaldehyde N-[1-(4-nitrophenyl)-3-acetyl-4-cyanopyrazol-5-yl]hydrazone 
• 30866-34-3 (E)-3-(4-Chloro-phenyl)-2-cyano-acrylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 

Relevant academic research and scientific papers

Investigation on corrosion protection behavior and adsorption of carbohydrazide-pyrazole compounds on mild steel in 15% HCl solution: Electrochemical and computational approach

The behavior of synthesized (E)-5-amino-3-(4-methoxyphenyl)-N′-(1-(4-methoxyphenyl)ethylidene)-1H-pyrazole-4-carbohydrazide [AMPC] and (E)-5-amino-N′-(4-chlorobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-4-carbohydrazide [ACPC] towards the corrosion protection of mild steel (MS) in 15% HCl solution was studied by gravimetric and electrochemical methods. The inhibitor AMPC and ACPC at an optimum concentration of 300 ppm showed 98.26% and 96.21% inhibition efficiency, respectively at 303 K temperature. Thermodynamic results conquer that both inhibitors followed mixed adsorption and results from polarization suggests the retardation of the cathodic as well as anodic reactions in presence of inhibitors. The Langmuir adsorption isotherm suggests the monolayer adsorption of inhibitors on the MS facet. The formation of protective layers of inhibitors on MS surface was confirmed by the outcomes of FESEM and AFM topographical details. The composition of adsorbed layers on the MS surface was studied by XPS analysis. The energy related to molecular orbital of inhibitors, and adsorption behavior was computationally examined by Density Functional Theory (DFT), calculation of Fukui functions and Monte-Carlo simulation (MCS) studies.

7-Amino-2-aryl/hetero-aryl-5-oxo-5,8-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitriles: Synthesis and adenosine receptor binding studies

A series of novel 7-amino-5-oxo-2-substituted-aryl/hetero-aryl-5,8-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitriles (4a–4t) was synthesized, characterized and evaluated for their binding affinity and selectivity towards hA1, hA2A/sub

Synthesis, DNA and protein interactions and human topoisomerase inhibition of novel Spiroacridine derivatives

Nine new spiroacridine derivatives were synthetized by introducing cyano-N-acylhydrazone group between the acridine and phenyl-substituted rings followed by spontaneous cyclization. The new compounds were assayed for their DNA binding properties, human to

Synthesis, anti-hepatitis B and C virus activity and antitumor screening of novel thiazolo[4,5-D]-pyrimidine derivatives

The paper describes the synthesis, antivirus and antitumor evaluation of novel thiazolo[4,5-d]pyrimidine derivatives. The target compounds 3a-h were synthesized by cyclocondensation of 4-amino-Ni-(phenylmethylidene)- 3-phenyl-2-thioxo-2,3-dihydrothiazole-

Synthesis of N-substituted γ-methylene γ-lactams

N-Substituted cyanoacetamides 1 were condensed with 1,2-diketones 2 under base catalysis to form ?-hydroxy ?-lactams 3. Treatment of 3 with acids gave novel fungicidal ?-methylene ?-lactams 4. The exocyclic double bond of 4b reacted reversibly with 4-toluene sulfinate. CSIRO 2005.

Pyrolysis of amino nitriles, cyanohydrazones, and cyanoacetamides. Part I. Elimination reaction of 1-arylmethyleneamino-1,2-dihydro-4, 6-dimethyl-2-oxopyridine-3-carbonitriles and substituted benzaldehyde cyanoacetylhydrazones

Pyrolysis of the Schiff bases of 1-arylmethyleneamino-1,2-dihydro-4, 6-dimethyl-2-oxopyridine-3-carbonitriles (1-5) has been studied. These compounds eliminate via a six-membered transition state to produce substituted benzonitriles and 2-hydroxy-4,6-dimethylpyridine-3-carbonitrile. These eliminations are unimolecular first-order reactions. The kinetic data gave a good correlation with σ0 values of the substituents on the aryl group with ρ = 0.83 at 520 K. Utilization of the pyrolytic reaction in synthesis of various benzonitriles is considered, and mechanistic information has been obtained by comparing the kinetic data and product analysis of the Schiff bases with their open-chain substituted benzaldehyde cyanoacetylhydrazones (6-9) analogues.

The Complex Reaction of Acetohydrazides with Unsaturated Diketones: Alternative Cyclizations to 1,2-Diazepin-3-ones and Pyrazolopyridines

The reaction of 2-cyanoacetohydrazide (1) and 2-(ethoxycarbonyl)acetohydrazide (26) with unsaturated 1,3-diketones leading with moderate yields to 1,2-diazepinones (3, 23, 24) and pyrazolopyridines (5, 15, 20, 25) together with the corresponding acetohydrazones have been studied.The reaction course depends on the temperature and the relative reactivity of the carbonyl groups of the starting materials.When one of these carbonyl groups is less reactive (benzoyl or ethoxycarbonyl groups), the reaction does not yield diazepinones but only pyrazolopyridines and/or acetohydrazones.