49800-23-9

Basic information

• Product Name: 1,2,3,4-TETRAHYDRO-1-NAPHTHYLAMINE HYDROCHLORIDE
• Synonyms: 1,2,3,4-TETRAHYDRO-1-NAPHTHYLAMINE HYDROCHLORIDE;1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YLAMINE HYDROCHLORIDE;TIMTEC-BB SBB000241;1-Amino-1,2,3,4-tetrahydronaphthaleneHCl;1-Amino-1,2,3,4-tetrahydronaphthalene Hydrochloride;1-Aminotetralin Hydrochloride;1-Naphthalenamine,1,2,3,4-tetrahydro-, hydrochloride (1:1)
• CAS NO: 49800-23-9
• Molecular Formula: C10H14ClN
• Molecular Weight: 183.68
• Product Categories: Amine Salts;Nitrogen Compounds;Organic Building Blocks
• Mol File: 49800-23-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 185-187 °C(lit.)
• Boiling Point: 302.39°C (rough estimate)
• Flash Point: 110.8 °C
• Appearance: /
• Density: 0.974 g/mL at 25 °C(lit.)
• Refractive Index: 1.6100 (estimate)
• CAS DataBase Reference: 1,2,3,4-TETRAHYDRO-1-NAPHTHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-TETRAHYDRO-1-NAPHTHYLAMINE HYDROCHLORIDE(49800-23-9)
• EPA Substance Registry System: 1,2,3,4-TETRAHYDRO-1-NAPHTHYLAMINE HYDROCHLORIDE(49800-23-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 49800-23-9(Hazardous Substances Data)

Usage

Uses

1,2,3,4-Tetrahydro-1-naphthylamine hydrochloride was used in enantiomeric separation using β-cyclodextrin-bonded negatively charged polyacrylamide gel-filled capillaries.

Upstream product

• 119-64-2 tetralin 

Relevant articles and documents

Synthesis of α-Substituted Primary Benzylamines through Copper-Catalyzed Cross-Dehydrogenative Coupling

A copper-catalyzed route to α-substituted, primary benzylamines by C-H functionalization of alkylarenes is described. The method directly affords the amine hydrochloride salt. Catalyst loadings down to 0.1 mol % in combination with scalability, insensitivity to air and moisture, and no need for column chromatography makes the procedure highly practical. The facile synthesis of the racemate of a blockbuster drug highlights the relevance for the development of pharmaceuticals. Preliminary mechanistic data are also included.