49827-06-7Relevant academic research and scientific papers
Facile synthetic approaches to 1-thiocyclopropanecarboxylates
Zhang, Xiansheng,Wu, Jingwei,Liu, Yuqiang,Xie, Yafei,Liu, Changying,Wang, Jianwu,Zhao, Guilong
, p. 799 - 811 (2017/07/22)
Two facile synthetic approaches to the novel biologically interesting 1-thiocyclopropanecarboxylates starting from corresponding thiols were developed. Approach A involved five steps with the key steps being the SN2 reactions of thiols and α-br
Synthesis method of eight-membered ring lactone compounds
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Paragraph 0021; 0022; 0034, (2017/01/02)
The invention provides a synthesis method of eight-membered ring lactone compounds and belongs to the technical field of medicinal chemistry. The synthesis method comprises steps as follows: firstly, alcohol is dissolved into anhydrous methylene chloride and mixed with acyl chloride for a reaction, and malonic acid compounds are obtained; the malonic acid compounds are dissolved into anhydrous methylene chloride and then is subjected to an olefin cross coupling reaction with allyl acetate, and acetoxyl malonic acid compounds are obtained; finally, under the catalysis of palladium acetate and triphenylphosphine, the acetoxyl malonic acid compounds with the concentration of 0.1 M-0.3 M are subjected to an intramolecular reaction with anhydrous N,N-dimethyl formamide taken as a solvent, and the eight-membered ring lactone compounds are obtained. The synthesis method is simple to operate, a substrate and a catalyst are required to be mixed simply, and the eight-membered ring compounds can be obtained. The synthesis method can be applied to preparation of different products such as products with ester, sulfonyl and methyl in different positions of an eight-membered ring.
A FACILE ROUTE TO HOMOCHIRAL SULFOXIDES
Burgess, Kevin,Henderson, Ian
, p. 3633 - 3636 (2007/10/02)
Biocatalytic resolution of methyl sulfinylacetates afford sulfoxides (R)-(1)-(6) in very high optical yields; the products have been used in a systematic study of the "SPAC" reaction, an asymmetric synthesis of γ-hydroxy-α,β-unsaturated esters.
