49844-93-1

Basic information

• Product Name: 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE
• Synonyms: 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE;2-Chloro-4-(methylsulphanyl)pyrimidine, 2-Chloro-4-(methylsulphonyl)-1,3-diazine
• CAS NO: 49844-93-1
• Molecular Formula: C5H5ClN2S
• Molecular Weight: 160.6246
• Product Categories: Building Blocks;Pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 49844-93-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 308.3 °C at 760 mmHg
• Flash Point: 140.3 °C
• Appearance: /
• Density: 1.37 g/cm³
• Vapor Pressure: 0.00125mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.45±0.20(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE(49844-93-1)
• EPA Substance Registry System: 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE(49844-93-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 49844-93-1(Hazardous Substances Data)

Usage

General Description

2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE is a chemical compound with the molecular formula C5H5ClN2S. It is a pyrimidine derivative with a chlorine atom and a methylsulfanyl group attached to the pyrimidine ring. 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has versatile reactivity due to the presence of both the chlorine and methylsulfanyl groups, making it an important building block in organic chemistry. The compound has various industrial applications and is used as a chemical intermediate in the production of a wide range of products. It is important to handle 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE with care, as it can be hazardous if not used properly.

InChI:InChI=1/C5H5ClN2S/c1-9-4-2-3-7-5(6)8-4/h2-3H,1H3

Upstream product

• 51674-12-5 4-methylsulfanyl-1H-pyrimidine-2-thione 
• 1722-12-9 2-chloropyrimidine 
• 2949-92-0 methanethiosulfonic acid S-methyl ester 
• 3934-20-1 2,6-Dichloropyrimidine 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 1422052-30-9 5-fluoro-3-(4-(methylthio)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine 
• 1450822-29-3 4-(methylsulfonyl)-N-phenylpyrimidin-2-amine 
• 1312572-51-2 4-[5-(3-methyl-5-{[4-(methylsulfanyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one 
• 1312572-57-8 4-[5-(3-methyl-5-{[4-(methylsulfinyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one 
• 1312572-96-5 4-[5-(3-methyl-5-{[4-(methylsulfonyl)-2-pyrimidinyl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one 

Relevant articles and documents

Synthesis of Alkylated Pyrimidines via Photoinduced Coupling Using Benzophenone as a Mediator

The synthesis of alkylated pyrimidines was achieved via benzophenone-mediated photoinduced coupling between saturated heterocycles and sulfonylpyrimidines. The pyrimidine ring was selectively introduced at the nonacidic C(sp3)-H bond proximal to heteroatoms including oxygen, nitrogen, and sulfur. This is a coupling reaction mediated solely by photoexcited benzophenone, an organic molecule, without the aid of any metallic catalysts or reagents.

QUINOLINONE PYRIMIDINES COMPOSITIONS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R6 are described herein.

Synthesis and herbicidal activity of 2-(3-(trifluoromethyl)-5-(alkoxy)-1H- pyrazol-1-yl)-4-aryloxypyrimidine derivatives

(Chemical Equation Presented) A series of 2-(3-(trifluoromethyl)-5-(alkoxy) -1H-pyrazol-l-yl)-4-aryloxypyrimidine derivatives were designed and synthesized. The structures of all the title compounds were confirmed by 1H NMR and elementary analy