49844-93-1

Usage

Uses

Used in Pharmaceutical Synthesis:
2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE is used as a chemical intermediate for the synthesis of pharmaceuticals. Its unique structure and reactivity allow for the development of various drug candidates with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE is utilized as a key intermediate in the production of agrochemicals. Its presence in these compounds can contribute to the effectiveness of pesticides, herbicides, and other agricultural products.
Used in Organic Chemistry Research:
2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE is employed as a versatile building block in organic chemistry research. Its reactivity with various functional groups makes it suitable for the synthesis of complex organic compounds and the exploration of novel chemical reactions.
It is crucial to handle 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE with care due to its potential hazards if not used properly, ensuring safety in both industrial and research settings.

InChI:InChI=1/C5H5ClN2S/c1-9-4-2-3-7-5(6)8-4/h2-3H,1H3

Upstream product

• 51674-12-5 4-methylsulfanyl-1H-pyrimidine-2-thione 
• 1722-12-9 2-chloropyrimidine 
• 2949-92-0 methanethiosulfonic acid S-methyl ester 
• 3934-20-1 2,6-Dichloropyrimidine 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 1450822-29-3 4-(methylsulfonyl)-N-phenylpyrimidin-2-amine 
• 1422052-30-9 5-fluoro-3-(4-(methylthio)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine 
• 1312572-51-2 4-[5-(3-methyl-5-{[4-(methylsulfanyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one 
• 1312572-57-8 4-[5-(3-methyl-5-{[4-(methylsulfinyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one 
• 1312572-96-5 4-[5-(3-methyl-5-{[4-(methylsulfonyl)-2-pyrimidinyl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one 

Relevant academic research and scientific papers

Synthesis of Alkylated Pyrimidines via Photoinduced Coupling Using Benzophenone as a Mediator

The synthesis of alkylated pyrimidines was achieved via benzophenone-mediated photoinduced coupling between saturated heterocycles and sulfonylpyrimidines. The pyrimidine ring was selectively introduced at the nonacidic C(sp3)-H bond proximal to heteroatoms including oxygen, nitrogen, and sulfur. This is a coupling reaction mediated solely by photoexcited benzophenone, an organic molecule, without the aid of any metallic catalysts or reagents.

Regioselective 2-Amination of Polychloropyrimidines

The regioselective amination of substituted di- and trichloropyrimidines affording the 2-substituted products is reported. While aryl- and heteroarylamines require the use of a dialkylbiarylphosphine-derived palladium catalyst for high efficiency, more nucleophilic dialkylamines produce 2-aminopyrimidines under noncatalyzed SNAr conditions. The key is the use of 5-trimethylsilyl-2,4-dichloropyrimidine as a surrogate for the parent dichloropyrimidine. For more challenging cases, the 2-chloro-4-thiomethoxy analogues were prepared and exclusively afford the desired 2-aminated-4-thiomethoxypyrimidine products.

QUINOLINONE PYRIMIDINES COMPOSITIONS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R6 are described herein.

SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS

Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).

Synthesis and herbicidal activity of 2-(3-(trifluoromethyl)-5-(alkoxy)-1H- pyrazol-1-yl)-4-aryloxypyrimidine derivatives

(Chemical Equation Presented) A series of 2-(3-(trifluoromethyl)-5-(alkoxy) -1H-pyrazol-l-yl)-4-aryloxypyrimidine derivatives were designed and synthesized. The structures of all the title compounds were confirmed by 1H NMR and elementary analy

Mixed Mg/Li amides of the type R2NMgCl·LiCl as highly efficient bases for the regioselective generation of functionalized aryl and heteroaryl magnesium compounds

(Chemical Equation Presented) Two are better than one: Mixed lithium-magnesium complexes of the type R2NMgCl·LiCl are kinetically highly active bases that convert a range of polyfunctional aromatic and heteroaromatic substrates into the corresponding magnesiated derivatives with high regioselectivity.