49845-74-1

Basic information

• Product Name: 2,2',2'',2'''-[(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol bis(toluene-p-sulphonate)
• Synonyms: 2,2',2'',2'''-[(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol bis(toluene-p-sulphonate)
• CAS NO: 49845-74-1
• Molecular Formula: C38H56N8O10S2
• Molecular Weight: 849.02884
• EINECS: 256-501-1
• Mol File: 49845-74-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 806.5°Cat760mmHg
• Flash Point: 441.5°C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 2,2',2'',2'''-[(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol bis(toluene-p-sulphonate)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2',2'',2'''-[(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol bis(toluene-p-sulphonate)(49845-74-1)
• EPA Substance Registry System: 2,2',2'',2'''-[(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol bis(toluene-p-sulphonate)(49845-74-1)

Safety Data

• Hazardous Substances Data: 49845-74-1(Hazardous Substances Data)

Usage

Molecular structure

The compound has a complex structure with a core consisting of a pyrimidine ring and a piperidine ring, connected by a dinitrilo group.

Functional groups

The compound contains multiple functional groups, including four ethanol groups and two toluene-p-sulphonate groups.

Sulphonate groups

The presence of two toluene-p-sulphonate groups indicates that the compound may have acidic or basic properties, depending on the reaction conditions.

Potential applications

Due to its complex and potentially reactive nature, the compound may have various applications in fields such as pharmaceuticals, materials science, or other industries.

Stability

The compound's stability may be influenced by the presence of multiple functional groups and its complex structure, which could affect its reactivity and potential uses.

Solubility

The presence of ethanol and toluene-p-sulphonate groups may contribute to the compound's solubility in various solvents, which could be important for its applications in different industries.

Reactivity

The compound's reactivity may be influenced by its multiple functional groups and complex structure, making it a potentially versatile chemical in various reactions and processes.

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 58-32-2 dipyridamole 

Relevant articles and documents

New dipyridamole salt with improved dissolution and oral bioavailability under hypochlorhydric conditions

The aim of this study was to develop new dipyridamole (DP) salts with pH-independent solubility for improving oral bioavailability under hypochlorhydria. Salt screening was carried out using nine counterions by the temperature gradient method. Six DP salts were obtained, and there was marked improvement in dissolution behavior for all DP salts in a neutral medium. Most DP salts were stable under accelerated conditions. On the basis of the dissolution and stability data, DP tosylate (DP/TS) was selected as a promising DP salt. The pharmacokinetics of DP and the promising DP salt were assessed in normal rats and omeprazole-treated rats as a hypochlorhydric model. After oral administration of DP/TS (10mg-DP/ kg) in normal rats, enhanced DP exposures with increased Cmax and AUC0-3 were observed compared with those with DP by ca. 2.8- and 1.7-fold, respectively. There was ca. 1 h delay of Tmax and ca. 62% reduction of AUC0-3 for DP in omeprazole-treated rats compared with those for DP in normal rats; however, oral absorption for DP/TS under hypochlorhydria was almost identical to that in normal rats. The newly developed DP/TS might provide better therapeutic efficacy in clinical use for hypochlorhydric patients.