498532-06-2Relevant articles and documents
Modulators of calcitonin and amylin receptor activity
-
Page/Page column 21-22, (2008/12/06)
In various aspects, the present invention relates to non-peptidic compounds, which modulate calcitonin and amylin receptor activity; to processes for the preparation of some such compounds; and to pharmaceutical compositions including such compounds. Compounds of the invention are useful as calcitonin and/or amylin agonists and in the treatment of bone diseases and metabolic diseases.
Hantzsch synthesis of pyrazolo[1′,2′:1,2]pyrazolo[3,4-b] pyridines: Partial agonists of the calcitonin receptor
Boros, Eric E.,Cowan, David J.,Cox, Richard F.,Mebrahtu, Makda M.,Rabinowitz, Michael H.,Thompson, James B.,Wolfe III, Lawrence A.
, p. 5331 - 5334 (2007/10/03)
Small molecule calcitonin receptor agonists are of potential utility in the treatment and prevention of osteoporosis. Bicycloeneamine 1 was a useful intermediate in the synthesis of pyrazolopyridine calcitonin receptor partial agonists 2a-f. Dihydropyridi
MODULATORS OF CALCITONIN AND AMYLIN ACTIVITY
-
, (2008/06/13)
In various aspects, the present invention relates to novel compounds, which modulate calcitonin and amylin receptor activity; to processes for the preparation of such compounds; and to pharmaceutical compositions including such compounds. Compounds of the
Synthetic derivatives
-
Page column 8-9, (2010/02/05)
This invention features a 5,6-dihydro-2-pyrone compound of formula (I), wherein R1 is H, OH, or C2?C5 alkoxyl; and R2 is 2-phenyl ethyl, 2-phenyl ethenyl, 2-heteroaryl ethyl, or 2-heteroaryl ethenyl; in which th
Asymmetric synthesis of kavalactones
-
, (2008/06/13)
This invention relates to preparation of enantio-enriched compounds, and more particularly to enantio-enriched kavalactone compounds and derivatives thereof. The methods provide compounds that are useful as reagents, or building blocks, in the constructio
CONDENSED HETEROCYCLIC COMPOUNDS AS CALCITONIN AGONISTS
-
Page/Page column 47, (2010/02/07)
The present invention relates to novel fused heterocyclic ring system compounds and methods for their use in the treatment and prevention of diseases or conditions which are related to irregular calcification.