49854-22-0

Upstream product

• 107954-46-1 N-(2-benzamido)-5-chloropentanamide 
• 72752-52-4 2-(piperidin-1-yl)benzonitrile 

Downstream Products

• 107954-55-2 Z-6H-1,2,3,4-tetrahydro-4-(phenylmethylene)pyrido<1,2-a>quinazolin-6-one 
• 107954-54-1 E-6H-1,2,3,4-tetrahydro-4-(phenylmethylene)pyrido<1,2-a>quinazolin-6-one 

Relevant academic research and scientific papers

Efficient construction of C=N double bonds via acceptorless dehydrogenative coupling

The efficient construction of C=N double bonds has been achieved by the Ir-catalyzed intramolecular acceptorless dehydrogenative cross-coupling of tertiary amines and amides. An iridium/2-hydroxypyridine complex was identified as the highly efficient catalyst. A number of quinazolinone derivatives was prepared in excellent yields. An iridium-mediated C-H activation mechanism is proposed. This finding provides an unprecedented strategy for the direct imidation of sp3 C-H bonds.

New Reactions of Deoxyvasicinone. Part 4.

Analogues of deoxyvasicinone (1) in which the pyrrolo ring is substituted, enlarged, or attached to the a face of the quinazolone system were prepared and several reactions of these analogues with electrophilic reagents have been investigated.