49854-61-7

Upstream product

• 824-75-9 p-fluorobenzamide 
• 684-16-2 Hexafluoroacetone 
• 52786-41-1 4-Fluoro-N-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-benzamide 

Downstream Products

• 49854-53-7 2-(4-fluoro-phenyl)-5-methoxy-5-phenyl-4,4-bis-trifluoromethyl-4,5-dihydro-oxazole 
• 53411-55-5 5-(4-fluoro-phenyl)-2,2,2-trimethoxy-3,3-bis-trifluoromethyl-2,3-dihydro-2λ⁵-[1,4,2]oxazaphosphole 
• 83081-29-2 5-Fluor-2-(4-fluorphenyl)-4-(trifluormethyl)oxazol 
• 117283-10-0 N-(1-Cyano-2,2,2-trifluoro-1-trifluoromethyl-ethyl)-4-fluoro-benzamide 
• 188397-74-2 2-(4-Fluoro-phenyl)-5,5-bis-trifluoromethyl-3,5-dihydro-imidazol-4-one 
• 139982-66-4 2-(4-Fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-3,5-dihydro-imidazol-4-one 
• 33469-33-9 2-(4-fluorophenyl)-1-methyl-4-(trifluoromethyl)-4H-imidazol 
• 188397-81-1 4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5-trifluoromethyl-3H-imidazol-4-yl]-benzamide 
• 188397-79-7 (4-Fluoro-phenyl)-[2-(4-fluoro-phenyl)-3-methyl-5-trifluoromethyl-3H-imidazol-4-yl]-methanone 
• 188397-75-3 2-(4-Fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-ol 
• 489418-83-9 4-(4-fluorophenyl)-9-methyl-2,2-bis(trifluoromethyl)-2H-pyrido[1,2-a][1,3,5]triazine 

Relevant academic research and scientific papers

Synthesis of bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4-diones and evaluation of their antibacterial and antifungal activities

A series of 5,5-bis(trifluoromethyl)-5,6-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones has been prepared by the cyclocondensation of N-acylimines of hexafluoroacetone and 6-aminouracils. The obtained compounds were screened for their activities against Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis and Bacillus anthracis) and Gram-negative (Escherichia coli) bacteria, as well as fungus Candida albicans. A few of the title compounds showed promising antimicrobial activity.