498580-71-5Relevant academic research and scientific papers
Synthesis of 2-thioxohydropyridine-3-carbonitrile, 2-alkylthiopyridine, thienopyridine, pyrazolopyridine derivatives and their theoretical calculations
Attaby, Fawzy A.,Elghandour, Ahmed H. H.,Mustafa, Hussein M.,Ibrahem, Yasser M.
, p. 561 - 569 (2002)
Cyanothioacetamide (1) reacted with but-2-enal (2) to give the corresponding 4-methyl-2-sulfanyl-pyridine-3-carbonitrile (7) which was used as a good starting material for the synthesis of 1-(3-amino-4-methylthieno[2,3-b] pyridin-2-yl)ethan-1-one (10), 3-amino-4-methylthieno[2,3-b]pyridine-2- carboxamide (15), 3-amino-4-methylthieno[2,3-b]pyridine-2-carboxylate (18) and 3-amino-4-methylthieno[2,3-b]pyridin-2-ylarylketone 25a-c through its reactions with each of (1-chloroacetone (8), 3-chloropentane-2,4-dione (11) or ethyl 2-chloro-3-oxo-butanoate (19)), 2-chloroacetamide (13), ethyl 2-chloroacetate (16) and 2-bromo-1-arylethan-1-one 23a-c, respectively. Considering the data of elemental analyses, IR, 1H NMR, mass spectra and theoretical calculations, structures of the newly synthesized heterocyclic compounds were elucidated.
