498582-06-2Relevant academic research and scientific papers
A versatile and efficient synthesis of 2-alkyl and 2-aryl-6-alkyl-2,3-dihydro-1H-pyridin-4-ones
Leflemme, Nicolas,Dallemagne, Patrick,Rault, Sylvain
, p. 1740 - 1746 (2002)
A versatile and efficient method for the preparation of 2-alkyl and 2-aryl-6-alkyl-2,3-dihydro-1H-pyridin-4-ones is described. The sequence involved the condensation of β-amino acids and t-butyl ketoester to give enaminoesters whose intramolecular cyclisation followed by an hydrolysis step afforded the expected products.
