499141-65-0Relevant academic research and scientific papers
Synthesis and antitumor activity of novel 1-(2′-alkyl(or phenyl)thioethoxy)methyl-5-fluorouracils and their oxidation products
Liu, Xue-Jun,Chen, Ru-Yu,Bai, Dong-Lu
, p. 543 - 548 (2007/10/03)
A series of novel 1-(2′-alkyl(or phenyl)-thioethoxy)methyl-5-fluorouracils (6) were synthesized in three steps from 5-fluorouracil. They were oxidized into sulfoxide (7) and sulfone (8) derivatives by NaIO4 and H2O2 30%/DEAD (diethyl azodicarboxylate), respectively, in high yields. In order to obtain structural information, sulfoxide 7g was characterized by X-ray diffraction analysis. The preliminary bioassay indicated that the compounds 6a and 7g exhibit potential antitumor activity.
